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                             December 29, 2020

       John Celebi
       President and Chief Executive Officer
       Sensei Biotherapeutics, Inc.
       1405 Research Blvd, Suite 125
       Rockville, MD 20850

                                                        Re: Sensei
Biotherapeutics, Inc.
                                                            Amendment No. 1
Draft Registration Statement on Form S-1
                                                            Submitted December
22, 2020
                                                            CIK No. 0001829802

       Dear Mr. Celebi:

             We have reviewed your amended draft registration statement and
have the following
       comments. In some of our comments, we may ask you to provide us with
information so we
       may better understand your disclosure.

              Please respond to this letter by providing the requested
information and either submitting
       an amended draft registration statement or publicly filing your
registration statement on
       EDGAR. If you do not believe our comments apply to your facts and
circumstances or do not
       believe an amendment is appropriate, please tell us why in your
response.

             After reviewing the information you provide in response to these
comments and your
       amended draft registration statement or filed registration statement, we
may have additional
       comments.

       Amendment No. 1 to Draft Registration Statement on Form S-1 Submitted
December 22, 2020

       Prospectus Summary
       Company Overview, page 1

   1.                                                   We note your response
to our prior comment 2. Please also revise the discussion of
                                                        clinical trials in the
Government Regulation section starting on page 118 to describe a
                                                        Phase 1/2 trial
specifically and distinguish it from the process of progressing through
                                                        Phase 1, Phase 2 and
then Phase 3.
       General

   2.                                                   We note your response
to our prior comment 16 and continue to note statements on the
                                                        company's website
relating to safety, efficacy, and FDA feedback that are inconsistent
 John Celebi
Sensei Biotherapeutics, Inc.
December 29, 2020
Page 2
       with your response to our previous comments and the amendments made to
the
       prospectus. Please advise us whether the company plans to revise its
website for
       consistency or if not, explain why you believe this is appropriate.
        You may contact Christine Torney at 202-551-3652 or Angela Connell at
202-551-3426
if you have questions regarding comments on the financial statements and
related
matters. Please contact Laura Crotty at 202-551-7614 or Tim Buchmiller at
202-551-3635 with
any other questions.



                                                            Sincerely,
FirstName LastNameJohn Celebi
                                                            Division of
Corporation Finance
Comapany NameSensei Biotherapeutics, Inc.
                                                            Office of Life
Sciences
December 29, 2020 Page 2
cc:       Michael E. Tenta, Esq.
FirstName LastName